Article
Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.
Development (Cambridge, England) - 1 Apr 2006
Bellipanni Gianfranco, Varga Máté, Maegawa Shingo, Imai Yoshiyuki, Kelly Christina, Myers Andrea Pomrehn, Chu Felicia, Talbot William S, Weinberg Eric S
Abstract excerpt
In Xenopus, Wnt signals and their transcriptional effector beta-catenin are required for the development of dorsal axial structures. In zebrafish, previous loss-of-function studies have not identified an essential role for beta-catenin in dorsal axis formation, but the maternal-effect mutation ichabod disrupts beta-catenin accumulation in dorsal nuclei and leads to a reduction of dorsoanterior derivatives. We...
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