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Article

Antisense targeting of engrailed-1 causes abnormal axis formation in mouse embryos.

Teratology - 1 May 1995

Sadler T W, Liu E T, Augustine K A

Abstract excerpt

Antisense oligonucleotide targeting of engrailed-1 (En-1) in early somite mouse embryos resulted in reduced En protein levels and produced abnormalities of the brain, face, and heart and shortening of the embryonic axis (caudal dysgenesis). Defects of the brain and limbs were consistent with abnormalities observed in null mutant mice described by other investigators. Abnormalities of the face and heart may be...

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PMID: 7482350
DOI: 10.1002/tera.1420510505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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