Article
Antisense attenuation of Wnt-1 and Wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis.
Developmental genetics - 1 Jan 1993
Augustine K, Liu E T, Sadler T W
Abstract excerpt
Wnt-1 and Wnt-3a proto-oncogenes have been implicated in the development of midbrain and hindbrain structures. Evidence for such a role has been derived from in situ hybridization studies showing Wnt-1 and -3a expression in developing cranial and spinal cord regions and from studies of mutant mic...
Topics
- Animals
- Base Sequence
- Brain
- Culture Techniques
- DNA
- Embryonic and Fetal Development
- Facial Bones
- Gene Expression
- Heart
- Heart Defects, Congenital
- Mice
- Mice, Inbred ICR
- Molecular Sequence Data
- Oligonucleotides, Antisense
- Phenotype
- Proto-Oncogenes
- RNA, Messenger
- Skull