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Article

Thioguanine-resistant mutant frequency in T-lymphocytes from a healthy human population.

Mutation research - 1 Feb 1992

Davies M J, Lovell D P, Anderson D

Abstract excerpt

Resistance to 6-thioguanine in T-lymphocytes was used to study in vivo somatic mutations in normal healthy adults. Donor age had a significant effect on mutant frequency at the hprt locus, showing an increase of 0.09/10(6) cells per year of age. No significant increase was associated with sex of donor, smoking habits, alcohol or coffee/tea intake, or X-ray exposure. The lower mutant frequency seen with...

Topics

Adult
Aging
Analysis of Variance
Clone Cells
Contraceptives, Oral
Drug Resistance
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reference Values

Regression Analysis

Smoking

T-Lymphocytes

Thioguanine

Source

Identifiers

PMID: 1370715
DOI: 10.1016/0027-5107(92)90045-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1370715-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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