Article
Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age.
Mutation research - 16 Jul 1994
Finette B A, Sullivan L M, O'Neill J P, Nicklas J A, Vacek P M, Albertini R J
Abstract excerpt
Somatic cell mutant frequencies at the hprt locus of the X-chromosome were measured with the T-lymphocyte cloning assay in a healthy pediatric population. Assays were performed on 49 subjects (29 males and 20 females) ranging in age from 0.08 to 15.2 years. A statistical analysis of the thioguani...
Topics
- Adolescent
- Adult
- Aging
- Cell Division
- Cell Survival
- Child
- Child, Preschool
- Clone Cells
- Drug Resistance
- Female
- Gene Frequency
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant
- Infant, Newborn