Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.

Carcinogenesis - 1 Sept 1992

Vrieling H, Thijssen J C, Rossi A M, van Dam F J, Natarajan A T, Tates A D, van Zeeland A A

Abstract excerpt

Recently, we have observed a small (36%), but significant, enhancement of the frequency of 6-thioguanine (6-TG)-resistant T-lymphocytes in blood from smokers. The molecular nature of 43 hypoxanthine-guanine phosphoribosyltransferase (hprt) mutant T-lymphocyte clones from nine smoking individuals...

Topics

Adult
Cells, Cultured
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
RNA Splicing
Smoking
T-Lymphocytes
Thioguanine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1394847
DOI: 10.1093/carcin/13.9.1625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1394847-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.PMID 1394847Read ↗

Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRT-locus in T lymphocytes of healthy adults.Semantic proximity Read ↗

Mutational spectra at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of nonsmoking and smoking lung cancer patients.Semantic proximity Read ↗

Factors affecting HPRT mutant frequency in T-lymphocytes of smokers and nonsmokers.Semantic proximity Read ↗

Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (hprt) gene of healthy people.Semantic proximity Read ↗

Influence of sex, smoking and age on human hprt mutation frequencies and spectra.Semantic proximity Read ↗

Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.Semantic proximity Read ↗

Frequency of HPRT mutant lymphocytes in a human control population as determined by the T-cell cloning procedure.Semantic proximity Read ↗

Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking.Semantic proximity Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

The influence of smoking and diet on the hypoxanthine phosphoribosyltransferase (hprt) mutant frequency in circulating T lymphocytes from a normal human population.Semantic proximity Read ↗

Hprt mutant frequency and GSTM1 genotype in non-smoking healthy individuals.Semantic proximity Read ↗

A comparison of somatic mutational spectra in healthy study populations from Russia, Sweden and USA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.