Article
Enhanced hprt mutant frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population.
Carcinogenesis - 1 Sept 1992
Vrieling H, Thijssen J C, Rossi A M, van Dam F J, Natarajan A T, Tates A D, van Zeeland A A
Abstract excerpt
Recently, we have observed a small (36%), but significant, enhancement of the frequency of 6-thioguanine (6-TG)-resistant T-lymphocytes in blood from smokers. The molecular nature of 43 hypoxanthine-guanine phosphoribosyltransferase (hprt) mutant T-lymphocyte clones from nine smoking individuals was determined to investigate whether the increase in hprt mutant frequency would lead to a changed mutation spectrum....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.