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Article

The transmission rate of the lacI transgene from the Big Blue mouse.

Mutation research - 1 Oct 1995

Heddle J A, Tao K, Swiger R R, Tucker J D

Abstract excerpt

Since transgenic mice are being used to analyze somatic and germinal mutation rates in vivo, it is of interest to know to what extent these mice are normal or abnormal in any way. During experiments designed to compare the mutational response of the transgene and an endogenous gene, Big Blue mice hemizygous for the transgene were bred to create a hybrid mouse in which the comparisons could be made. The fraction...

Topics

Animals
Crosses, Genetic
Female
Heterozygote
Lac Operon
Male
Meiosis
Mice
Mice, Transgenic
Mutagenesis, Site-Directed
Phenotype
Sex Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transgenes

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Identifiers

PMID: 7477053
DOI: 10.1016/0165-7992(95)00047-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7477053-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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