Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.

doi:10.1016/s1383-5742(98)00024-6

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Article

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.

Mutation research - 1 Jan 1999

Hill K A, Buettner V L, Glickman B W, Sommer S S

Abstract excerpt

The Big Blue transgenic mouse mutation detection system provides a powerful approach for measuring spontaneous and induced mutations in vivo. The observed mutations may contain a fraction of ex vivo or prokaryotic mutational events. Indeed, a modified, selectable form of the Big Blue assay seem t...

Topics

Animals
Artifacts
Bacterial Proteins
DNA Mutational Analysis
Escherichia coli
Escherichia coli Proteins
Lac Repressors
Mice
Mice, Transgenic
Mosaicism
Mutation
Repressor Proteins
Reproducibility of Results
Transgenes

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