Article
Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.
Mutation research - 1 Jan 1999
Hill K A, Buettner V L, Glickman B W, Sommer S S
Abstract excerpt
The Big Blue transgenic mouse mutation detection system provides a powerful approach for measuring spontaneous and induced mutations in vivo. The observed mutations may contain a fraction of ex vivo or prokaryotic mutational events. Indeed, a modified, selectable form of the Big Blue assay seem to generate artifactual mutants under certain circumstances. Herein we review the evidence that circular mutants (i.e.,...
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