Article
A selectable system for mutation detection in the Big Blue lacI transgenic mouse system: what happens to the mutational spectra over time.
Mutation research - 10 Jun 1996
Knöll A, Jacobson D P, Nishino H, Kretz P L, Short J M, Sommer S S
Abstract excerpt
Transgenic animals offer a powerful tool to study the mechanisms of spontaneous and induced mutagenesis in vivo. Herein we used a test version of a growth selectable assay to obtain spontaneous mutants in a lacI target transgene recovered from lacI transgenic B6C3F1 mice (Big Blue). This selection system may have certain advantages relative to the more established plaque screening system for mutation detection...
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