A selectable system for mutation detection in the Big Blue lacI transgenic mouse system: what happens to the mutational spectra over time.

doi:10.1016/0027-5107(95)00159-x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A selectable system for mutation detection in the Big Blue lacI transgenic mouse system: what happens to the mutational spectra over time.

Mutation research - 10 Jun 1996

Knöll A, Jacobson D P, Nishino H, Kretz P L, Short J M, Sommer S S

Abstract excerpt

Transgenic animals offer a powerful tool to study the mechanisms of spontaneous and induced mutagenesis in vivo. Herein we used a test version of a growth selectable assay to obtain spontaneous mutants in a lacI target transgene recovered from lacI transgenic B6C3F1 mice (Big Blue). This selectio...

Topics

Animals
Bacterial Proteins
Bacteriophage lambda
Base Sequence
Brain
DNA Mutational Analysis
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Genetic Vectors
Germ Cells
Lac Repressors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Transgenic

Molecular Sequence Data

Mutation

Organ Specificity

Source

Open in PubMed

Identifiers

PMID: 8676922
DOI: 10.1016/0027-5107(95)00159-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8676922-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A selectable system for mutation detection in the Big Blue lacI transgenic mouse system: what happens to the mutational spectra over time.PMID 8676922Read ↗

Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type.Semantic proximity Read ↗

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.Semantic proximity Read ↗

Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice.Semantic proximity Read ↗

Spontaneous mutation in lacI transgenic mice: a comparison of tissues.Semantic proximity Read ↗

Quantifying in vivo somatic mutations using transgenic mouse model systems.Semantic proximity Read ↗

Spontaneous mutations in lacI-containing lambda lysogens derived from transgenic mice: the observed patterns differ in liver and spleen.Semantic proximity Read ↗

Comparative analysis of DNA mutations in lacI transgenic mice with age.Semantic proximity Read ↗

Quantifying in vivo somatic mutations using transgenic mouse model systems.Semantic proximity Read ↗

On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice.Semantic proximity Read ↗

Sequence spectra of spontaneous lacZ gene mutations in transgenic mouse somatic and germline tissues.Semantic proximity Read ↗

Use of transgenic mouse models for studying somatic mutations in aging.Semantic proximity Read ↗

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.