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Article

Use of transgenic mouse models for studying somatic mutations in aging.

Mutation research - 1 Oct 1995

Martus H J, Dollé M E, Gossen J A, Boerrigter M E, Vijg J

Abstract excerpt

Theories on the causes of aging, based on the accumulation of somatic mutations in tissues of an organism, were formulated decades ago, but remain insufficiently tested. Transgenic animals, equipped with integrated bacterial reporter genes that can be efficiently rescued from total genomic DNA of all tissues and organs, represent ideal tools for investigating the types and frequencies of spontaneous mutants...

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PMID: 7565876
DOI: 10.1016/0921-8734(95)00025-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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