Use of transgenic mouse models for studying somatic mutations in aging.

doi:10.1016/0921-8734(95)00025-2

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Article

Use of transgenic mouse models for studying somatic mutations in aging.

Mutation research - 1 Oct 1995

Martus H J, Dollé M E, Gossen J A, Boerrigter M E, Vijg J

Abstract excerpt

Theories on the causes of aging, based on the accumulation of somatic mutations in tissues of an organism, were formulated decades ago, but remain insufficiently tested. Transgenic animals, equipped with integrated bacterial reporter genes that can be efficiently rescued from total genomic DNA of...

Topics

Aging
Animals
Bacteriophage lambda
Gene Deletion
Genetic Vectors
Hypoxanthine Phosphoribosyltransferase
Lac Operon
Mice
Mice, Transgenic
Mutation
Plasmids
Transgenes

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