Article
Spontaneous mutation in lacI transgenic mice: a comparison of tissues.
Mutagenesis - 1 Mar 1998
de Boer J G, Provost S, Gorelick N, Tindall K, Glickman B W
Abstract excerpt
The nature of spontaneous mutations in the lacI transgene of Big Blue mice was determined in selected tissues. The mutant frequencies ranged from 2.5 x 10(-5) to 7.1 x 10(-5) for liver, spleen, bladder, stomach, kidney, bone marrow, lung and skin. We also determined the DNA sequence alterations i...
Topics
- Animals
- Bacterial Proteins
- DNA Mutational Analysis
- Escherichia coli Proteins
- Female
- Frameshift Mutation
- Gene Deletion
- Lac Repressors
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenesis, Insertional
- Mutation
- Organ Specificity
- Point Mutation
- Repressor Proteins