Article
p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.
Oncogene - 20 Jul 1995
Nishino H, Knöll A, Buettner V L, Frisk C S, Maruta Y, Haavik J, Sommer S S
Abstract excerpt
Transgenic mouse mutation detection systems offer a powerful tool for analysis of spontaneous and induced mutations in vivo. Mice doubly transgenic for a null mutation of the p53 tumor suppressor gene and a lambda shuttle vector harboring the lacI gene were utilized to examine the rate and pattern of spontaneous somatic mutation of the lacI transgene in vivo. Three somatic tissues were examined: liver, spleen and...
Topics
- Animals
- Base Sequence
- Brain
- Breeding
- Female
- Gene Frequency
- Genes, p53
- Lac Operon
- Liver
- Male
- Mice
- Mice, Transgenic