Article
p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.
Oncogene - 20 Jul 1995
Nishino H, Knöll A, Buettner V L, Frisk C S, Maruta Y, Haavik J, Sommer S S
Abstract excerpt
Transgenic mouse mutation detection systems offer a powerful tool for analysis of spontaneous and induced mutations in vivo. Mice doubly transgenic for a null mutation of the p53 tumor suppressor gene and a lambda shuttle vector harboring the lacI gene were utilized to examine the rate and pattern of spontaneous somatic mutation of the lacI transgene in vivo. Three somatic tissues were examined: liver, spleen and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.