Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents.

Mutation research - 9 May 2001

Monroe J J, Manjanatha M G, Skopek T R

Abstract excerpt

The lacI transgene used in the Big Blue (BB) mouse and rat mutation assays typically displays spontaneous mutation frequencies in the 5x10(-5) range. Recently, the bone marrow and bladder of the Big Blue rat were reported to have, by an order of magnitude, the lowest spontaneous mutation frequencies ever observed for lacI in a transgenic animal, approaching the value for endogenous targets such as hprt (...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to CpG Islands
Share to Cytosine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA Primers

Share to Hypoxanthine Phosphoribosyltransferase

Share to Lac Operon

Share to Mice, Transgenic

Source

Identifiers

PMID: 11336978
DOI: 10.1016/s0027-5107(01)00081-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents.PMID 11336978Read ↗

Spontaneous mutation in lacI transgenic mice: a comparison of tissues.Semantic proximity Read ↗

Effect of target gene CpG content on spontaneous mutation in299 transgenic mice.Semantic proximity Read ↗

Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice.Semantic proximity Read ↗

Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type.Semantic proximity Read ↗

Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influence.Semantic proximity Read ↗

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived.Semantic proximity Read ↗

Spontaneous mutation spectrum at the lambda cII locus in liver, lung, and spleen tissue of Big Blue transgenic mice.Semantic proximity Read ↗

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system.Semantic proximity Read ↗

Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.Semantic proximity Read ↗

Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice.Semantic proximity Read ↗

Spontaneous mutants recovered from liver and germ cell tissue of low copy number lacI transgenic rats.Semantic proximity Read ↗

Frequency and spectrum of ENU-induced mutation in the Phi X174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.