Article
Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1997
de Boer J G, Erfle H, Walsh D, Holcroft J, Provost J S, Rogers B, Tindall K R, Glickman B W
Abstract excerpt
The advent of transgenic technology has greatly facilitated the study of mutation in animals in vivo. The Big Blue mouse system, transgenic for the lacI gene, permits not only the quantification of mutations in different tissues but also provides for the generation of in vivo-derived mutational spectra. This report details the sequence alterations of 348 spontaneous mutations recovered from the liver of...
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