Article
Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice.
Mutation research - 1 Jun 1994
Winegar R A, Lutze L H, Hamer J D, O'Loughlin K G, Mirsalis J C
Abstract excerpt
Ionizing radiation induces gene mutations (point mutations, deletions and insertions) as well as chromosome damage in mammalian cells. Although these effects have been studied extensively in cells in culture, until recently it has not been possible to analyze the mutagenic potential of ionizing radiation in vivo, especially at the molecular level. The development of transgenic mutagenesis systems has now made it...
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