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Article

DNA-ligase activities appear normal in the CHO mutant EM9.

Mutation research - 1 Jan 2000

Chan J Y, Thompson L H, Becker F F

Abstract excerpt

The Chinese hamster ovary (CHO) mutant strain EM9 was previously shown to be hypersensitive to killing by ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS), to have a 12-fold increased baseline incidence of sister-chromatid exchanges (SCE), and to be defective in rejoining DNA strand breaks after treatment with EMS, MMS, or X-rays. A study was performed to determine if the primary biochemical defect...

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Identifiers

PMID: 6738565
DOI: 10.1016/0167-8817(84)90027-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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DNA-ligase activities appear normal in the CHO mutant EM9.PMID 6738565Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

Mitochondrial DNA ligase III function is independent of Xrcc1.Semantic proximity Read ↗

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.Semantic proximity Read ↗

Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.Semantic proximity Read ↗

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.Semantic proximity Read ↗

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A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.Semantic proximity Read ↗

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.Semantic proximity Read ↗

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