Article
DNA-ligase activities appear normal in the CHO mutant EM9.
Mutation research - 1 Jan 2000
Chan J Y, Thompson L H, Becker F F
Abstract excerpt
The Chinese hamster ovary (CHO) mutant strain EM9 was previously shown to be hypersensitive to killing by ethyl methanesulfonate (EMS) and methyl methanesulfonate (MMS), to have a 12-fold increased baseline incidence of sister-chromatid exchanges (SCE), and to be defective in rejoining DNA strand breaks after treatment with EMS, MMS, or X-rays. A study was performed to determine if the primary biochemical defect...
Topics
- Animals
- Cell Line
- Cricetinae
- Cricetulus
- DNA Ligases
- DNA Repair
- Female
- Hot Temperature
- Mutation
- Ovary
- Polynucleotide Ligases
- Sodium Chloride