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Article

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.

Mutation research - 26 Feb 1998

Domínguez I, Daza P, Natarajan A T, Cortés F

Abstract excerpt

The fluorescence plus Giemsa (FPG) and fluorescence in situ hybridization (FISH) techniques have been used to determine, respectively, the frequencies of sister chromatid exchanges (SCEs) and stable chromosome aberrations (translocations) induced by different concentrations of BrdU in the Chinese hamster ovary cell mutant EM9 and its parental line AA8. The results indicate that BrdU induced a high frequency of...

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PMID: 9626966
DOI: 10.1016/s0027-5107(97)00241-8

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A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.PMID 9626966Read ↗

Abnormally high incidence of SCE in three successive cell cycles in the CHO mutant EM9 as detected by a three-way immunoperoxidase differential staining.Semantic proximity Read ↗

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

DNA-strand breaks associated with halogenated pyrimidine incorporation.Semantic proximity Read ↗

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.Semantic proximity Read ↗

High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.Semantic proximity Read ↗

Role of various DNA repair pathways in chromosomal inversion formation in CHO mutants.Semantic proximity Read ↗

The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.Semantic proximity Read ↗

Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants.Semantic proximity Read ↗

Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.Semantic proximity Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

DNA-ligase activities appear normal in the CHO mutant EM9.Semantic proximity Read ↗

Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein.Semantic proximity Read ↗

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