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Article

Mitochondrial DNA ligase III function is independent of Xrcc1.

Nucleic acids research - 15 Oct 2000

Lakshmipathy U, Campbell C

Abstract excerpt

Hamster EM9 cells, which lack Xrcc1 protein, have reduced levels of DNA ligase III and are defective in nuclear base excision repair. The Xrcc1 protein stabilizes DNA ligase III and may even play a direct role in catalyzing base excision repair. Since DNA ligase III is also thought to function in mitochondrial base excision repair, it seemed likely that mitochondrial DNA ligase III function would also be...

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Identifiers

PMID: 11024166
DOI: 10.1093/nar/28.20.3880
PMCID: PMC110795

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