Altered DNA ligase III activity in the CHO EM9 mutant.

doi:10.1016/0921-8777(94)90081-7

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Article

Altered DNA ligase III activity in the CHO EM9 mutant.

Mutation research - 1 Mar 1994

Ljungquist S, Kenne K, Olsson L, Sandström M

Abstract excerpt

Delayed joining of DNA strand breaks and a high spontaneous level of sister-chromatid exchanges (SCEs) are characteristics of the mutant cell strain EM9 of Chinese hamster ovary (CHO) cells. The introduction of the human gene XRCC1 into EM9 cells reverts the phenotypic properties of EM9 to those...

Topics

Adenosine Monophosphate
Animals
Blotting, Western
CHO Cells
Chromatography, Gel
Cricetinae
DNA Ligase ATP
DNA Ligases
DNA Repair
DNA-Binding Proteins
Enzyme Activation
Humans
Mutation
Poly-ADP-Ribose Binding Proteins
X-ray Repair Cross Complementing Protein 1
Xenopus Proteins

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