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Article

Altered DNA ligase III activity in the CHO EM9 mutant.

Mutation research - 1 Mar 1994

Ljungquist S, Kenne K, Olsson L, Sandström M

Abstract excerpt

Delayed joining of DNA strand breaks and a high spontaneous level of sister-chromatid exchanges (SCEs) are characteristics of the mutant cell strain EM9 of Chinese hamster ovary (CHO) cells. The introduction of the human gene XRCC1 into EM9 cells reverts the phenotypic properties of EM9 to those of the wild type. We have investigated both DNA ligase activities and a protein which stimulates DNA ligase activity in...

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Source

Identifiers

PMID: 7510367
DOI: 10.1016/0921-8777(94)90081-7

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Altered DNA ligase III activity in the CHO EM9 mutant.PMID 7510367Read ↗

DNA-ligase activities appear normal in the CHO mutant EM9.Semantic proximity Read ↗

Mitochondrial DNA ligase III function is independent of Xrcc1.Semantic proximity Read ↗

Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9.Semantic proximity Read ↗

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells.Semantic proximity Read ↗

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.Semantic proximity Read ↗

Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein.Semantic proximity Read ↗

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.Semantic proximity Read ↗

Characterization of the hamster FancG/Xrcc9 gene and mutations in CHO UV40 and NM3.Semantic proximity Read ↗

DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency.Semantic proximity Read ↗

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