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The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.

Mutation research - 26 Sept 2008

Mateos Santiago, Domínguez Inmaculada, Cantero Gloria, Pastor Nuria, Campanella Claudia, Cortés Felipe

Abstract excerpt

It has been recently proposed that hypomethylation of DNA induced by 5-azacytidine (5-azaC) leads to reduced chromatid decatenation that ends up in endoreduplication, most likely due to a failure in topo II function [S. Mateos, I. Domínguez, N. Pastor, G. Cantero, F. Cortés, The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells, Mutat. Res. 578 (2005) 33-42]. The Chinese hamster...

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PMID: 18640132
DOI: 10.1016/j.mrfmmm.2008.06.007

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The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.PMID 18640132Read ↗

High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.Semantic proximity Read ↗

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

Abnormally high incidence of SCE in three successive cell cycles in the CHO mutant EM9 as detected by a three-way immunoperoxidase differential staining.Semantic proximity Read ↗

DNA-strand breaks associated with halogenated pyrimidine incorporation.Semantic proximity Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.Semantic proximity Read ↗

DNA-ligase activities appear normal in the CHO mutant EM9.Semantic proximity Read ↗

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

Gene silencing and endogenous DNA methylation in mammalian cells.Semantic proximity Read ↗

Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.Semantic proximity Read ↗

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.Semantic proximity Read ↗

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