Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.

doi:10.1016/0027-5107(93)90096-x

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Article

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.

Mutation research - 1 Aug 1993

Cortés F, Piñero J, Palitti F

Abstract excerpt

The possible relationship between topoisomerase activities and the occurrence of SCE and chromosomal aberrations was investigated in the CHO ethyl methanesulfonate-sensitive mutant EM9 and its parental line, AA8. The Topo II inhibitor m-AMSA induced fewer SCE in EM9 than in AA8, mainly when given...

Topics

Amsacrine
Animals
CHO Cells
Camptothecin
Chromosome Aberrations
Cricetinae
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Mutation
Sister Chromatid Exchange
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors

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