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Article

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

Nucleic acids research - 1 Dec 2002

Woods Timothy, Wang Wei, Convery Erin, Errami Abdellatif, Zdzienicka Malgorzata Z, Meek Katheryn

Abstract excerpt

We recently described a CHO DSBR mutant belonging to the XRCC7 complementation group (XR-C2) that has the interesting phenotype of being radiosensitive, but having only a modest defect in VDJ recombination. This cell line expresses only slightly reduced levels of DNA-PKcs but has undetectable DNA-PK activity. Limited sequence analyses of DNA-PKcs transcripts from XR-C2 revealed a point mutation that results in an...

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Identifiers

PMID: 12466535
DOI: 10.1093/nar/gkf625
PMCID: PMC137947

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