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Article

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.

Mutation research - 7 Aug 1998

Barrows L R, Holden J A, Anderson M, D'Arpa P

Abstract excerpt

We have analyzed the X-ray-sensitive CHO mutant cell line EM9 for sensitivity to the topoisomerase I inhibitor comptothecin. These cells exhibit defective repair of single strand DNA breaks. Recently, EM9 were complemented the DNA ligase III interactive protein, XRCC1. Defective XRCC1 apparently accounts for the low DNA ligase III activity that may explain the single-strand break repair deficiency of EM9 cells....

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Source

Identifiers

PMID: 9739812
DOI: 10.1016/s0921-8777(98)00022-6

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.PMID 9739812Read ↗

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.Semantic proximity Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

DNA-ligase activities appear normal in the CHO mutant EM9.Semantic proximity Read ↗

The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand BreaksSemantic proximity Read ↗

Characterization of the hamster FancG/Xrcc9 gene and mutations in CHO UV40 and NM3.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.Semantic proximity Read ↗

Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9.Semantic proximity Read ↗

Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group.Semantic proximity Read ↗

Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.Semantic proximity Read ↗

Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein.Semantic proximity Read ↗

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