Article
Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.
Mutation research - 26 Feb 1998
Op het Veld C W, Jansen J, Zdzienicka M Z, Vrieling H, van Zeeland A A
Abstract excerpt
The Chinese hamster cell mutant EM-C11, which is hypersensitive to the cell killing effects of alkylating agents compared to its parental line CHO9, has been used to study the impact of base excision repair on the mutagenic effects of DNA methylation damage. This cell line has a defect in the xrc...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Cricetulus
- DNA Primers
- DNA-Binding Proteins
- Hypoxanthine Phosphoribosyltransferase
- Methyl Methanesulfonate
- Mutagens
- Mutation
- X-ray Repair Cross Complementing Protein 1