Article
DNA-strand breaks associated with halogenated pyrimidine incorporation.
Mutation research - 1 Jan 2000
Dillehay L E, Thompson L H, Carrano A V
Abstract excerpt
The alkaline elution of bromodeoxyuridine-containing (BrdUrd) DNA and chlorodeoxyuridine-containing ( CldUrd ) DNA was studied in two CHO lines, the parental AA8 and a mutant line, EM9 , which has a defect in repairing strand breaks and a 12-fold elevated baseline frequency of SCE. BrdUrd-DNA was found to have alkali-labile sites as well as direct breaks, neither of which were increased significantly by prior...
Topics
- Animals
- Benzamides
- Bromodeoxyuridine
- Cell Line
- Cricetinae
- Cricetulus
- DNA Repair
- DNA Replication
- Deoxyuridine
- Female
- Kinetics
- Mutation