Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.

doi:10.1016/0027-5107(93)90116-w

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Article

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.

Mutation research - 1 Feb 1993

Palitti F, Cortés F, Bassi L, Di Chiara D, Fiore M, Pinero J

Abstract excerpt

The induction of chromosomal alterations by camptothecin (CPT), an inhibitor of DNA topoisomerase I, in the G2 stage was studied in a CHO mutant cell line EM9, which has an elevated baseline frequency of SCEs, and in its parental cell line AA8. EM9 cells were found to be more sensitive to CPT tha...

Topics

Animals
CHO Cells
Camptothecin
Chromosome Aberrations
Chromosomes
Cricetinae
G2 Phase
Mutagens
Mutation
Topoisomerase I Inhibitors

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