Article
Molecular characterization of mutations at the hprt locus in V79 Chinese hamster cells induced by bleomycin in the presence of inhibitors of DNA repair.
Mutation research - 1 Jul 1991
Köberle B, Speit G
Abstract excerpt
The molecular basis of bleomycin (BLM)-induced mutations in the absence and presence of inhibitors of DNA repair was investigated in V79 cells with Southern hybridization techniques. 43% of the BLM-induced thioguanine-resistant mutants suffer from large alterations of hprt DNA sequences. To under...
Topics
- Animals
- Benzamides
- Bleomycin
- Blotting, Southern
- Cell Line
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Cytarabine
- DNA Damage
- DNA Repair
- Dideoxynucleosides
- Hypoxanthine Phosphoribosyltransferase
- Mutagens
- Mutation
- Nucleic Acid Hybridization