Article
The role of deoxyribonucleotide metabolism in 5-bromo-2'-deoxyuridine mutagenesis in mammalian cells.
Mutation research - 1 Jan 2000
Kaufman E R
Abstract excerpt
The effects of deoxyribonucleoside triphosphate (dNTP) pool imbalance on the induction of mutations and sister-chromatid exchanges (SCEs) by 5-bromo-2'-deoxyuridine (BrdUrd) in mammalian cells is reviewed. The INC BrdUrd mutagenesis protocol involves the incorporation of BrdUrd into DNA under conditions of specific dNTP pool imbalance, while the REP BrdUrd mutagenesis protocol involves the replication of...
Topics
- Animals
- Bromodeoxyuridine
- Cells, Cultured
- DNA Replication
- Deoxyribonucleotides
- Mutation
- Sister Chromatid Exchange