Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of deoxyribonucleotide metabolism in 5-bromo-2'-deoxyuridine mutagenesis in mammalian cells.

Mutation research - 1 Jan 2000

Kaufman E R

Abstract excerpt

The effects of deoxyribonucleoside triphosphate (dNTP) pool imbalance on the induction of mutations and sister-chromatid exchanges (SCEs) by 5-bromo-2'-deoxyuridine (BrdUrd) in mammalian cells is reviewed. The INC BrdUrd mutagenesis protocol involves the incorporation of BrdUrd into DNA under conditions of specific dNTP pool imbalance, while the REP BrdUrd mutagenesis protocol involves the replication of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Cells, Cultured
Share to Deoxyribonucleotides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Mutation

Share to Sister Chromatid Exchange

Source

Identifiers

PMID: 3393158
DOI: 10.1016/0027-5107(88)90077-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of deoxyribonucleotide metabolism in 5-bromo-2'-deoxyuridine mutagenesis in mammalian cells.PMID 3393158Read ↗

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Semantic proximity Read ↗

Mutagenesis and deoxyribonucleotide pool imbalance.Semantic proximity Read ↗

International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability.Semantic proximity Read ↗

Cost of rNTP/dNTP pool imbalance at the replication fork.Semantic proximity Read ↗

Genetic effects of 2-aminopurine in mammalian cells.Semantic proximity Read ↗

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances.Semantic proximity Read ↗

Role of carcinogen-modified deoxynucleotide precursors in mutagenesis.Semantic proximity Read ↗

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism.Semantic proximity Read ↗

Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate.Semantic proximity Read ↗

A mammalian-like DNA damage response of fission yeast to nucleoside analogs.Semantic proximity Read ↗

The Balancing Act of Ribonucleotides in DNA.Semantic proximity Read ↗

Suppression of mismatched mutation by p53: a mechanism for guarding genomic integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.