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High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.

Mutation research - 26 Apr 2002

Pastor Nuria, José Flores Maria, Domínguez Inmaculada, Mateos Santiago, Cortés Felipe

Abstract excerpt

An uncommonly high yield of spontaneous endoreduplication is a feature of the CHO mutant EM9, besides its defective repair of single, as well as double-DNA strand-breaks and its extraordinarily elevated yield of sister chromatid exchanges (SCEs) after bromodeoxyuridine (BrdU) incorporation into DNA. Since the nuclear enzyme topoisomerase II (topo II) has been reported to be responsible for the segregation of...

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PMID: 11943617
DOI: 10.1016/s1383-5718(02)00029-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor.PMID 11943617Read ↗

The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA.Semantic proximity Read ↗

Abnormally high incidence of SCE in three successive cell cycles in the CHO mutant EM9 as detected by a three-way immunoperoxidase differential staining.Semantic proximity Read ↗

Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8.Semantic proximity Read ↗

Testing the SCE mechanism with non-poisoning topoisomerase II inhibitors.Semantic proximity Read ↗

A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9.Semantic proximity Read ↗

A comparative study of genotoxic effects of anti-topoisomerase II drugs ICRF-193 and bufalin in Chinese hamster ovary cells.Semantic proximity Read ↗

Investigating the hows and whys of DNA endoreduplication.Semantic proximity Read ↗

DNA-strand breaks associated with halogenated pyrimidine incorporation.Semantic proximity Read ↗

Higher G2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I.Semantic proximity Read ↗

A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

Altered DNA ligase III activity in the CHO EM9 mutant.Semantic proximity Read ↗

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