Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

doi:10.1038/304596a0

Back to search

Article

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Nature - 1 Jan 2000

Land H, Parada L F, Weinberg R A

Abstract excerpt

Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the p...

Topics

Animals
Antigens, Viral
Antigens, Viral, Tumor
Cell Line
Cell Transformation, Viral
Cells, Cultured
Fibroblasts
Gene Expression Regulation
Genes, Viral
Genetic Complementation Test
Mice
Oncogenes
Phenotype
Polyomavirus

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.