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Transformation of Human and Murine Fibroblasts without Viral Oncoproteins

15 Jul 2005

Abstract excerpt

Murine embryo fibroblasts are readily transformed by the introduction of specific combinations of oncogenes; however, the expression of those same oncogenes in human cells fails to convert such cells to tumorigenicity. Using normal human and murine embryonic fibroblasts, we show that the transformation of human cells requires several additional alterations beyond those required to transform comparable murine...

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PMID: 16024784
DOI: 10.1128/mcb.25.15.6464-6474.2005

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