Article
Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist.
Environmental health perspectives - 1 Jun 1991
Ragozzino M M, Kuo A, DeGregori J, Kohl N, Ruley H E
Abstract excerpt
Gene transfer experiments have defined limitations with regard to the ability of individual oncogenes to transform cultured cells to a tumorigenic state. The stable transformation of REF52 cells by either the ras or sis oncogenes requires the continuous expression of a second collaborating oncoge...
Topics
- Adenovirus Early Proteins
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cricetinae
- Epistasis, Genetic
- Fibroblasts
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma