Article
Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist.
Environmental health perspectives - 1 Jun 1991
Ragozzino M M, Kuo A, DeGregori J, Kohl N, Ruley H E
Abstract excerpt
Gene transfer experiments have defined limitations with regard to the ability of individual oncogenes to transform cultured cells to a tumorigenic state. The stable transformation of REF52 cells by either the ras or sis oncogenes requires the continuous expression of a second collaborating oncogene, such as adenovirus-5 E1A or SV40 large T-antigen. Our studies suggest that the function of the nuclear...
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