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Article

Malignant transformation of early passage rodent cells by a single mutated human oncogene.

Nature - 1 Jan 2000

Spandidos D A, Wilkie N M

Abstract excerpt

When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal Ha-ras-1 proto-oncogene only induces immortalization. Therefore, mutated Ha-ras-1 does not require a cooperating gene to trigger malignant conversion and ras genes may be involved in the process of tumorigenesis at an...

Topics

Animals
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Gene Expression Regulation
Humans
Karyotyping
Mutation
Oncogenes
Proto-Oncogene Mas
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 6462235
DOI: 10.1038/310469a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6462235-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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