Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.

Nature - 1 Jan 2000

Schwab M, Varmus H E, Bishop J M

Abstract excerpt

Proto-oncogenes represent a group of eukaryotic genes whose activated forms are implicated in the development of cancer. We have recently identified a human gene, N-myc, that is distantly related to the proto-oncogene c-myc. N-myc is expressed at abnormally high levels consequent to amplification in numerous human neuroblastoma cell lines and metastatic neuroblastoma tumours. In addition, enhanced expression of...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
Humans
Mice
Mice, Nude
Neoplasms, Experimental
Oncogenes
Phenotype
Proto-Oncogene Mas
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Transfection

Source

Identifiers

PMID: 4040214
DOI: 10.1038/316160a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-4040214-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.PMID 4040214Read ↗

Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.Semantic proximity Read ↗

ras and c-myc oncoproteins during tumor progression in the uterine cervix.Semantic proximity Read ↗

Reviewing once more the c-myc and Ras collaborationSemantic proximity Read ↗

Nestin Is a Potential Mediator of Malignancy in Human Neuroblastoma CellsSemantic proximity Read ↗

Cooperation of oncogenes in the multistep transformation of established fibroblasts in culture.Semantic proximity Read ↗

Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.Semantic proximity Read ↗

Altered growth and phenotype in clonal mycN transfectants of the SK-N-SH neuroblastoma cell line.Semantic proximity Read ↗

Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in MiceSemantic proximity Read ↗

Differential expression of N-myc in phenotypically distinct subclones of a human neuroblastoma cell line.Semantic proximity Read ↗

Direct recruitment of N-myc to target gene promotersSemantic proximity Read ↗

Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.Semantic proximity Read ↗

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.