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Article

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.

Nature - 1 Jan 2000

Schwab M, Varmus H E, Bishop J M

Abstract excerpt

Proto-oncogenes represent a group of eukaryotic genes whose activated forms are implicated in the development of cancer. We have recently identified a human gene, N-myc, that is distantly related to the proto-oncogene c-myc. N-myc is expressed at abnormally high levels consequent to amplification in numerous human neuroblastoma cell lines and metastatic neuroblastoma tumours. In addition, enhanced expression of...

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Identifiers

PMID: 4040214
DOI: 10.1038/316160a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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