Cysteine endopeptidases and their inhibitors in malignant progression of rat embryo fibroblasts.

doi:10.1515/bchm3.1992.373.2.589

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Article

Cysteine endopeptidases and their inhibitors in malignant progression of rat embryo fibroblasts.

Biological chemistry Hoppe-Seyler - 1 Jul 1992

Sloane B F, Rozhin J, Moin K, Ziegler G, Fong D, Muschel R J

Abstract excerpt

Cathepsins B and L and their endogenous inhibitors were evaluated in rat embryo fibroblast lines which have been developed as a model system for the study of malignant progression and metastatic capability. Three groups of lines were analyzed: 1) immortalized/non-tumorigenic, 2) tumorigenic/metastatic lines transfected with c-Ha-ras, and 3) metastatic revertants transfected with c-Ha-ras+the E1A region of...

Topics

Adenoviridae
Animals
Cathepsin B
Cathepsin L
Cathepsins
Cells, Cultured
Cysteine Endopeptidases
Cysteine Proteinase Inhibitors
Endopeptidases
Female
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, myc

Genes, ras

Immunoblotting

Neoplasm Metastasis

Neoplasms, Experimental

Nucleic Acid Hybridization

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1515088
DOI: 10.1515/bchm3.1992.373.2.589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1515088-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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