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Article

Oncogene transformation frequency of nonsenescent SFME cells is increased by c-myc.

Oncogene - 1 Mar 1991

Rawson C, Shirahata S, Collodi P, Natsuno T, Barnes D

Abstract excerpt

Immortalized, postcrisis mouse embryo cell cultures derived in serum-containing medium display genomic abnormalities and an altered, preneoplastic phenotype. These lines can be transformed with single oncogenes, such as Ha-ras, while efficient transformation of precrisis, genomically unaltered rodent embryo cultures require cooperating oncogenes, such as Ha-ras and the mouse c-myc gene constitutively expressed....

Topics

Animals
Blotting, Southern
Cell Line, Transformed
Cells, Cultured
DNA
Genes, ras
Mice
Mutation
Oncogenes
Proto-Oncogene Proteins c-myc
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2011405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2011405-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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