Article
Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.
Journal of virology - 1 Jul 1996
Ray R B, Lagging L M, Meyer K, Ray R
Abstract excerpt
We have previously demonstrated that hepatitis C virus (HCV) core protein regulates cellular protooncogenes at the transcriptional level; this observation implicates core protein in the alteration of normal hepatocyte growth. In the present study, the transforming potential of the HCV core gene w...
Topics
- Animals
- Base Sequence
- Cell Adhesion
- Cell Transformation, Viral
- Cells, Cultured
- Cloning, Molecular
- DNA Primers
- Fibroblasts
- Gene Expression
- Hepacivirus
- Humans
- Mice
- Mice, Nude
- Molecular Sequence Data
- Neoplasms, Experimental
- Phenotype
- Proto-Oncogene Proteins p21(ras)
- Rats