Article
A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1992
Zambetti G P, Olson D, Labow M, Levine A J
Abstract excerpt
Mutant p53 and activated ras cDNA clones cooperate to fully transform primary rat embryo fibroblasts in cell culture, whereas neither cDNA alone results in the full transformation of these cells. The mutant p53 protein may be required to initiate the transformation event with ras. Alternatively,...
Topics
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Gene Expression
- Genes, p53
- Genes, ras
- In Vitro Techniques
- Mutation
- Proto-Oncogene Proteins p21(ras)
- Rats
- Transfection
- Tumor Suppressor Protein p53