Expression of the human beta globin gene and 5'-deletion mutants in erythroleukemic mouse cells studied by DNA mediated gene transfer.

Article

Expression of the human beta globin gene and 5'-deletion mutants in erythroleukemic mouse cells studied by DNA mediated gene transfer.

Anticancer research - 1 Jan 2000

Spandidos D A

Abstract excerpt

A recombinant plasmid pTKH beta GHp-3 carrying genomic human DNA sequences coding for the beta globin gene covalently linked to the thymidine kinase gene of HSV-1 and the ampicillin resistance region of a bacterial plasmid has been constructed. Using Bal 31 exonuclease, deletion mutants have been...

Topics

Animals
Base Sequence
Beta-Globulins
Chromosome Deletion
DNA
Gene Expression Regulation
Humans
Leukemia, Erythroblastic, Acute
Mice
Mutation
Nucleic Acid Hybridization
Transcription, Genetic

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