Article
Expression of human globin genes in transgenic mice carrying the beta-globin gene cluster with a mutation causing G gamma beta + hereditary persistence of fetal hemoglobin.
Annals of the New York Academy of Sciences - 1 Jan 1990
Tanaka M, Nolan J A, Bhargava A K, Rood K, Collins F S, Weissman S M, Forget B G, Chamberlain J W
Abstract excerpt
We have introduced into the mouse germ line the 40-kilobase (kb) Kpn I fragment containing the beta-globin gene cluster from an individual with a non-deletion form of hereditary persistence of fetal hemoglobin (HPFH) believed to be due to a point mutation at position -202 of the G gamma-globin gene. The G gamma-globin gene, as well as the beta-globin gene, was expressed in adult erythroid tissues of the resulting...
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