Expression of the human gamma-globin gene after retroviral transfer to transformed erythroid cells.

doi:10.1021/bi00470a019

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Article

Expression of the human gamma-globin gene after retroviral transfer to transformed erythroid cells.

Biochemistry - 8 May 1990

Rixon M W, Harris E A, Gelinas R E

Abstract excerpt

Regulation of the human fetal (gamma) globin gene and a series of mutant gamma-globin genes was studied after retroviral transfer into erythroid cells with fetal or adult patterns of endogenous globin gene expression. Steady-state RNA from a virally transferred A gamma-globin gene with a normal promoter increased after induction of erythroid maturation of murine erythroleukemia cells and comprised from 2% to 23%...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
Fetus
Gene Expression
Genes
Globins
Humans
Introns
Leukemia, Erythroblastic, Acute
Moloney murine leukemia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Poly A

Promoter Regions, Genetic

RNA

RNA, Messenger

Retroviridae

Source

Open in PubMed

Identifiers

PMID: 1693523
DOI: 10.1021/bi00470a019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1693523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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