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Article

Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.

Blood - 15 Feb 1990

Ulrich M J, Ley T J

Abstract excerpt

We examined the importance of cis-acting regulatory elements of the human gamma-globin gene promoter in a cell line (K562) where this gene normally functions. A gamma-Globin promoter fragments were fused to the neomycin phosphotransferase (neoR) gene in a plasmid-based vector and transiently transfected by electroporation into K562 cells. Correctly initiated "A gamma-neo" transcripts were detected with an S1...

Topics

Beta-Globulins
DNA
Electrophysiology
Fetal Hemoglobin
Humans
Leukemia, Erythroblastic, Acute
Leukemia, Experimental
Leukemia, Myeloid
Mutation
Promoter Regions, Genetic
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

gamma-Globulins

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Identifiers

PMID: 1689192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689192-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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