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Article

Retroviral transfer of a human fetal globin gene carrying the -202 G gamma beta (+)-HPFH mutation into the human erythroleukemia line, KMOE.

Hemoglobin - 1 Jan 1991

Stoeckert C J

Abstract excerpt

The presence of point mutations at position -202 relative to the mRNA Cap site of both human fetal gamma-globin genes is linked with elevated fetal globin levels in adults. The question addressed in this study is whether the -202 mutation affects gamma-globin gene expression in the same manner as the -117 hereditary persistence of fetal hemoglobin (HPFH) A gamma-globin mutation. The -117 mutation was found to...

Topics

Fetal Hemoglobin
Gene Expression Regulation, Neoplastic
Genetic Vectors
Globins
Humans
Leukemia, Erythroblastic, Acute
Mutation
Neoplasm Proteins
Promoter Regions, Genetic
RNA Caps
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Neoplasm

Recombinant Proteins

Retroviridae

Thalassemia

Tumor Cells, Cultured

Source

Identifiers

PMID: 1723972
DOI: 10.3109/03630269109027878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1723972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Retroviral transfer of a human fetal globin gene carrying the -202 G gamma beta (+)-HPFH mutation into the human erythroleukemia line, KMOE.PMID 1723972Read ↗

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