Article
The role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression.
Nucleic acids research - 15 Jul 2000
Drew L R, Tang D C, Berg P E, Rodgers G P
Abstract excerpt
The molecular mechanisms which govern the develop-mental specificity of human beta-globin gene transcription have been studied in K562 cells, a human eyrthroleukemia line that expresses minimal beta-globin. Protein-binding analysis reveals that the 5' region contains three elements bound by trans-acting factors, beta-protein 1 (BP1) and beta-protein 2 (BP2). In vitro mutagenesis of each individual element in a...
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