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Article

Constitutive production of alpha and beta interferons in mutant human cell lines.

Journal of virology - 1 Jun 1994

McKendry R, Pellegrini S, Kerr I M, Stark G R

Abstract excerpt

Alpha and beta interferons control expression of a selectable marker in the human hypoxanthine phosphoribosyltransferase-negative cell line 2fTGH, in which transcription of gpt is regulated by the upstream region of an interferon-responsive human gene. Selection of mutagenized 2fTGH cells in hypoxanthine-aminopterin-thymidine medium yielded mutants in one recessive (C1) and two dominant (C2 and C3)...

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Identifiers

PMID: 8189543
DOI: 10.1128/JVI.68.6.4057-4062.1994
PMCID: PMC236917

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