Constitutive production of alpha and beta interferons in mutant human cell lines.

doi:10.1128/JVI.68.6.4057-4062.1994

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Article

Constitutive production of alpha and beta interferons in mutant human cell lines.

Journal of virology - 1 Jun 1994

McKendry R, Pellegrini S, Kerr I M, Stark G R

Abstract excerpt

Alpha and beta interferons control expression of a selectable marker in the human hypoxanthine phosphoribosyltransferase-negative cell line 2fTGH, in which transcription of gpt is regulated by the upstream region of an interferon-responsive human gene. Selection of mutagenized 2fTGH cells in hypo...

Topics

Base Sequence
Cell Line
DNA Probes
Genes, Dominant
Genes, Recessive
Genetic Complementation Test
Humans
Interferon-alpha
Interferon-beta
Molecular Sequence Data
Mutation
RNA, Messenger

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