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Article

The molecular basis of HPFH in a British family identified by heteroduplex formation.

British journal of haematology - 1 May 1993

Craig J E, Sheerin S M, Barnetson R, Thein S L

Abstract excerpt

Single-base substitutions in the immediate 5'-flanking region of the fetal G gamma and A gamma globin genes have been associated with non-deletional forms of hereditary persistence of fetal haemoglobin (HPFH). Previously, the sole promoter mutation associated with HPFH in British individuals has been the T to C substitution at position -198 relative to the A gamma globin gene CAP site. We have investigated a...

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PMID: 7687855
DOI: 10.1111/j.1365-2141.1993.tb03032.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The molecular basis of HPFH in a British family identified by heteroduplex formation.PMID 7687855Read ↗

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The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Semantic proximity Read ↗

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Molecular Basis of Hereditary Persistence of Fetal HemoglobinSemantic proximity Read ↗

A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression.Semantic proximity Read ↗

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