Article
The molecular basis of HPFH in a British family identified by heteroduplex formation.
British journal of haematology - 1 May 1993
Craig J E, Sheerin S M, Barnetson R, Thein S L
Abstract excerpt
Single-base substitutions in the immediate 5'-flanking region of the fetal G gamma and A gamma globin genes have been associated with non-deletional forms of hereditary persistence of fetal haemoglobin (HPFH). Previously, the sole promoter mutation associated with HPFH in British individuals has...
Topics
- Base Sequence
- Child, Preschool
- DNA
- Family
- Female
- Fetal Hemoglobin
- Globins
- Hemoglobinopathies
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Heteroduplexes
- Polymerase Chain Reaction