Article
Comparative studies of nondeletional HPFH gamma-globin gene promoters.
Experimental hematology - 1 Jul 1993
Motum P I, Lindeman R, Harvey M P, Trent R J
Abstract excerpt
The -198 T-->C and the -175 T-->C transitions involving the proximal gamma-globin gene promoter are associated with the hereditary persistence of fetal hemoglobin (HPFH) phenotype and have been demonstrated to increase promoter activity in erythroid cells using transient and stable transfection systems. The above base changes are thought to alter the binding of different transcription regulatory proteins. Another...
Topics
- Base Sequence
- Binding Sites
- DNA
- Fetal Hemoglobin
- Globins
- Hemoglobinopathies
- Humans
- Leukemia, Erythroblastic, Acute
- Molecular Sequence Data
- Mutation
- Point Mutation
- Promoter Regions, Genetic