Article
Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.
The EMBO journal - 1 Jan 1990
Collis P, Antoniou M, Grosveld F
Abstract excerpt
The human beta-globin dominant control region (DCR) was previously identified as a region from the 5' end of the human beta-globin locus which directs high level, site of integration-independent, copy number-dependent expression on a linked human beta-globin gene in transgenic mice and stably tra...
Topics
- Animals
- Cloning, Molecular
- Deoxyribonuclease I
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Globins
- Humans
- Introns
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Transgenic
- Mutation
- Promoter Regions, Genetic
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured