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Article

Polygenic risk scores, adiposity, and disease transition in type 2 diabetes and colorectal cancer comorbidity: a population-based Chinese cohort study.

BMC cancer - 20 Aug 2026

Liu Bing, Xu Jue, Jiang Caixia, Zhang Yan, Wang Xin

Abstract excerpt

BACKGROUND: The co-occurrence of type 2 diabetes (T2D) and colorectal cancer (CRC) represents an increasing public health concern, contributing to greater clinical complexity and poorer outcomes. This study aimed to evaluate whether polygenic risk scores (PRS) for T2D and CRC are associated with the risk of T2D-CRC comorbidity and to investigate their potential interaction with body mass index (BMI). METHODS: A...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Adiposity
Body Mass Index

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

China

Cohort Studies

Colorectal Neoplasms

Comorbidity

Diabetes Mellitus, Type 2

Genetic Predisposition to Disease

Genetic Risk Score

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Risk Factors

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 42754861
DOI: 10.1186/s12885-026-16806-5
PMCID: PMC13584306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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