Article

Polygenic risk scores, adiposity, and disease transition in type 2 diabetes and colorectal cancer comorbidity: a population-based Chinese cohort study

2026-05-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> The co-occurrence of type 2 diabetes (T2D) and colorectal cancer (CRC) represents an increasing public health concern, contributing to greater clinical complexity and poorer outcomes. This study aimed to evaluate whether polygenic risk scores (PRS) for T2D and CRC are associated with the risk of T2D–CRC comorbidity and to investigate their potential interactio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63464619-7b45-5f37-ab49-d3fcfe91bcab
DOI: 10.21203/rs.3.rs-9465720/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk scores, adiposity, and disease transition in type 2 diabetes and colorectal cancer comorbidity: a population-based Chinese cohort studyDOI 10.21203/rs.3.rs-9465720/v1Read

Type 2 Diabetes, Glycemic Traits and Overall Cancer Risk: A Large-Scale Prospective Cohort Study.Semantic proximity Read

Disproportionately increased risk of adiposity-related cancers in adults with early onset type 2 diabetes and obesitySemantic proximity Read

Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related MorbiditiesSemantic proximity Read

Physical Activity, Genetic Susceptibility, and Risk of Colorectal Cancer in Type 2 Diabetes: A Large Population-Based Cohort Study.Semantic proximity Read

Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Semantic proximity Read

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan.Semantic proximity Read

Using genetics to decipher the link between type 2 diabetes and cancer: shared aetiology or downstream consequence?Semantic proximity Read

Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.Semantic proximity Read

Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes.Semantic proximity Read

Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk.Semantic proximity Read

Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study.Semantic proximity Read

Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases.Semantic proximity Read